To answer the question posed in the title of this editorial, the data required are the in situ luminal fluid concentrations of NH4+, H+, HCO3− and H2PO4− in the various nephron segments. These data can only be provided by superficial nephron micropuncture data in the cortex, micropuncture of the tip of the loop of Henle of deep nephrons, and microcatheterization of inner medullary collecting ducts. Hence, one limitation of this analysis is the assumption that the above values represent reasonable estimates of in vivo events in all nephrons in the kidney.There is another source of data to examine to help gain insights into events in vivo, studies with isolated nephron segments or with membrane vesicles derived from these structures. Data fro...
The static measurement of hydrogen ion activity in body fluids reflects complex interrelationships b...
The renal collecting system serves the fine-tuning of renal acid-base secretion. Acid-secretory type...
Characterization of acidification by the isolated perfused rat kidney: Evidence for adaptation by th...
To answer the question posed in the title of this editorial, the data required are the in situ lumin...
The kidneys' major functions in regulating the acid-base balance of body fluids are (1) to conserve ...
The kidney participates in the maintenance of acid-base homeostasis by 1) reabsorption of the filter...
The final site of titration of the urinary buffers is the collecting tubule. When this process fails...
On the mechanism of bicarbonate exit from renal proximal tubular cells. We compare here the results ...
AbstractThe traditional approach to acid-base balance, namely, that the metabolism of certain dietar...
Bicarbonate transport in collecting duct segments during chloride-depletion alkalosis. Renal correct...
The transport processes that underly the reabsorption of bicarbonate and the excretion of acid by th...
The cortical distal tubule, a very heterogeneous segment starting at the macula densa and ending wit...
The cortical distal tubule, a very heterogeneous segmant sarting at the macula densa and ending with...
A theoretical model was developed to examine the role of physical and chemical factors in the contro...
Distal urinary acidification from Homer Smith to the present. Since Smith's time, the essential role...
The static measurement of hydrogen ion activity in body fluids reflects complex interrelationships b...
The renal collecting system serves the fine-tuning of renal acid-base secretion. Acid-secretory type...
Characterization of acidification by the isolated perfused rat kidney: Evidence for adaptation by th...
To answer the question posed in the title of this editorial, the data required are the in situ lumin...
The kidneys' major functions in regulating the acid-base balance of body fluids are (1) to conserve ...
The kidney participates in the maintenance of acid-base homeostasis by 1) reabsorption of the filter...
The final site of titration of the urinary buffers is the collecting tubule. When this process fails...
On the mechanism of bicarbonate exit from renal proximal tubular cells. We compare here the results ...
AbstractThe traditional approach to acid-base balance, namely, that the metabolism of certain dietar...
Bicarbonate transport in collecting duct segments during chloride-depletion alkalosis. Renal correct...
The transport processes that underly the reabsorption of bicarbonate and the excretion of acid by th...
The cortical distal tubule, a very heterogeneous segment starting at the macula densa and ending wit...
The cortical distal tubule, a very heterogeneous segmant sarting at the macula densa and ending with...
A theoretical model was developed to examine the role of physical and chemical factors in the contro...
Distal urinary acidification from Homer Smith to the present. Since Smith's time, the essential role...
The static measurement of hydrogen ion activity in body fluids reflects complex interrelationships b...
The renal collecting system serves the fine-tuning of renal acid-base secretion. Acid-secretory type...
Characterization of acidification by the isolated perfused rat kidney: Evidence for adaptation by th...